解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Ovarian surface epithelium (OSE) is considered to give rise to epithelial ovarian carcinomas (EOCs). To elucidate early processes contributing to the development of EOCs from the OSE, two batches of primary human OSE cells were transduced with non-viral human genes (mutant Cdk4, cyclinD1 and hTERT) so as to efficientl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp007
更新日期:2009-03-01 00:00:00
abstract::The G protein-coupled formylpeptide receptor (FPR), known to mediate phagocytic leucocyte chemotaxis in response to bacterial- and host-derived agonists, was expressed by tumor cells in specimens of surgically removed more highly malignant human gliomas. In human glioblastoma cell lines, FPR activation increased cell ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn266
更新日期:2009-02-01 00:00:00
abstract::We have previously demonstrated that betel quid containing safrole induced DNA adducts are highly associated with the development of oral squamous cell carcinoma (OSCC) in Taiwan. Sulfotransferase (SULT) is essential for the formation of these adducts. To elucidate the effects of SULT1A1 haplotypes on OSCC susceptibil...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn283
更新日期:2009-02-01 00:00:00
abstract::A growing number of studies indicate a link between oxidative stress and cancer. We previously developed a rat model of renal cell carcinoma (RCC) induced by ferric nitrilotriacetate (Fe-NTA). Here, we performed a genome-wide analysis to study characteristics of genomic alteration and identify putative genes involved ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn255
更新日期:2009-01-01 00:00:00
abstract::Androgens and estrogens may play a role in gastric cancer etiology. To investigate the association of gastric cancer with single-nucleotide polymorphisms (SNPs) in six genes (COMT, CYP1B1, CYP17A1, CYP19A1, HSD17B1 and SHBG) involved in estrogen and androgen synthesis and metabolism, 58 haplotype-tagging SNPs were gen...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn258
更新日期:2009-01-01 00:00:00
abstract::The activity of nuclear transcription factors is often regulated by specific kinase-signaling pathways. We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK). Here, we show that DD...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn213
更新日期:2009-01-01 00:00:00
abstract::We have investigated the role of the signaling intermediate, EPS8, in tumor progression using a model system and in vivo. HN4 primary tumor cells express low levels of EPS8, similar to normal keratinocytes, and show minimal invasion in vitro in response to epidermal growth factor, whereas HN12 cells express high level...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn252
更新日期:2009-01-01 00:00:00
abstract::A mismatch between metabolic demand and oxygen delivery leads to microenvironmental changes in solid tumors. The resulting tumor hypoxia is associated with malignant progression, therapy resistance and poor prognosis. However, the molecular mechanisms underlying therapy resistance in hypoxic tumors are not fully under...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn231
更新日期:2008-12-01 00:00:00
abstract::Previously, we reported the identification of a novel immunoglobulin-like cell adhesion molecule hepaCAM that is frequently downregulated and inhibits cell growth in hepatocellular carcinoma. In this study, we show that the expression of hepaCAM is suppressed in diverse human cancers. Aiming to evaluate the biological...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn226
更新日期:2008-12-01 00:00:00
abstract::Acutely transforming retrovirus AKT8 in rodent T cell lymphoma (Akt) phosphorylates and regulates the function of many cellular proteins involved in processes such as metabolism, apoptosis and proliferation. However, the precise mechanisms by which Akt promotes cell survival and inhibits apoptosis have been characteri...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn197
更新日期:2008-11-01 00:00:00
abstract::Dietary resistant starch (RS), as a high amylose maize starch (HAMS), prevents dietary protein-induced colonocyte genetic damage in rats, possibly through the short-chain fatty acid (SCFA) butyrate produced by large bowel bacterial RS fermentation. Increasing butyrate availability may improve colonic health and dietar...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn173
更新日期:2008-11-01 00:00:00
abstract::Common genetic variation may play an important role in altering lung cancer risk. We conducted a pathway-based candidate gene evaluation to identify genetic variations that may be associated with lung cancer in a population-based case-control study in Xuan Wei, China (122 cases and 111 controls). A total of 1260 singl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn178
更新日期:2008-10-01 00:00:00
abstract::p53-upregulated modulator of apoptosis (PUMA) plays an essential role in p53-dependent apoptosis following DNA damage. PUMA also mediates apoptosis independent of p53. In this study, we investigated the role and mechanism of PUMA induction in response to serum starvation in p53-deficient cancer cells. Following serum ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn150
更新日期:2008-10-01 00:00:00
abstract::Resveratrol is a phytochemical that has been under consideration for use as a prostate cancer chemopreventive agent. However, the efficacy, as well as the mechanisms of action of resveratrol on prostate cancer prevention, remains largely unknown. This study seeks to address these questions and examine the cancer preve...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn131
更新日期:2008-10-01 00:00:00
abstract::Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer in smokers and non-smokers that arises in most cases from small airway epithelial cells. PAC has a high mortality due to its aggressive behavior and resistance to cancer therapeutics. We have shown previously that the proliferation of human PAC cells NC...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn041
更新日期:2008-10-01 00:00:00
abstract::Histone deacetylase (HDAC) inhibitors have the potential to derepress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. In the present study, we screened several garlic-derived small organosulfur compounds for their ability to inhibit HDAC activity in vitro. Among the organosul...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn165
更新日期:2008-09-01 00:00:00
abstract::Reactive oxygen species (ROS) are a major cause of cellular injury in an increasing number of diseases, including cancer. Most ROS are created in the cell through normal cellular metabolism. They can be produced by environmental insults such as ultraviolet light and toxic chemicals, as well as by the inflammatory proc...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgn142
更新日期:2008-09-01 00:00:00
abstract::Intake of dietary factors that serve as methyl group donors may influence promoter hypermethylation in colorectal carcinogenesis. We investigated whether dietary folate, vitamin B2 and vitamin B6, methionine and alcohol were associated with mutL homologue 1 (MLH1) hypermethylation and the related molecular phenotypes ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn074
更新日期:2008-09-01 00:00:00
abstract::Ulcerative colitis is a dynamic, chronic inflammatory condition of the colon associated with an increased colon cancer risk. Ginkgo biloba is a putative antioxidant and has been used for thousands of years to treat a variety of ailments. The aim of this study was to test whether the standardized G.biloba extract, EGb ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn143
更新日期:2008-09-01 00:00:00
abstract::The mutagen sensitivity assay is an in vitro measure of DNA repair capacity used to evaluate intrinsic susceptibility for cancer. The high heritability of mutagen sensitivity to different mutagens validates the use of this phenotype to predict cancer susceptibility. However, genetic determinants of mutagen sensitivity...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn121
更新日期:2008-07-01 00:00:00
abstract::Alk(en)yl trisulfides (R-SSS-R') are organosulfur compounds produced by crushed garlic and other Allium vegetables. We found that these compounds exhibit potent anticancer effects through the reaction with microtubules, causing cell cycle arrest. Nine alk(en)yl trisulfides including dimethyl trisulfide, diethyl trisul...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn124
更新日期:2008-07-01 00:00:00
abstract::Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn126
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:The hepatitis B virus x gene (HBx) is a promiscuous transactivator implicated in the development of hepatocellular carcinoma (HCC). The present study was designed to investigate the molecular events regulated by HBx. METHODS:Genomic and proteomic expression profiling was performed in Huh7 HCC cells transfec...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn111
更新日期:2008-06-01 00:00:00
abstract::It is now unanimously accepted that neoplastic cells tend to become less susceptible to the growth regulatory effects of transforming growth factor-beta1 (TGF-beta1), mainly because of reduced expression and/or activity of TGF-beta1-specific receptors, as reported for many human cancers including colon cancer. Consequ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn106
更新日期:2008-05-01 00:00:00
abstract::The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC). In this study, genotype distributions for 10 polymorphisms in the human counterparts for three mouse candidate Pas1 genes, KRAS, CASC1...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn048
更新日期:2008-05-01 00:00:00
abstract::Adipocytokines are a group of adipocyte-secreted proteins that have significant effects on the metabolism of lipids and carbohydrates, as well as numerous other processes. A number of recent studies have indicated that some adipocytokines may significantly influence the proliferation of malignant cells in vitro, where...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn080
更新日期:2008-05-01 00:00:00
abstract::The Notch pathway plays a key role in the development and is increasingly recognized for its importance in cancer. We demonstrated previously the overexpression of Notch-1 and its ligands in gliomas and showed that their knockdown inhibits glioma cell proliferation and survival. To elucidate the mechanisms downstream ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn079
更新日期:2008-05-01 00:00:00
abstract::The genes that are involved in estrogen biosynthesis, cellular binding and metabolism may contribute to breast cancer susceptibility. We examined the effect of the CYP17 promoter T --> C polymorphism and its interactions with the reproductive history, exogenous hormone use and selected lifestyle risk factors on breast...
journal_title:Carcinogenesis
pub_type: 杂志文章,多中心研究
doi:10.1093/carcin/bgn042
更新日期:2008-04-01 00:00:00
abstract::Prostate stromal and epithelial cell communication is important in prostate functioning and cancer development. Primary human stromal cells from normal prostate stromal cells (PRSC) maintain a smooth muscle phenotype, whereas those from prostate cancer (6S) display reactive and fibroblastic characteristics. Dihydrotes...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn011
更新日期:2008-04-01 00:00:00
abstract::FEZ1/LZTS1 is a tumor suppressor gene that is frequently altered in human cancers of different histotypes. We have reported previously that LZTS1 is downregulated in high-grade bladder cancer and that its restoration suppresses tumorigenicity in urothelial carcinoma cells. To further investigate the role of LZTS1 in t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn006
更新日期:2008-04-01 00:00:00
abstract::DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within Lynch syndrome. MSI-H is characterized by length alterations within simple repeated sequences, microsatellites. Lynch syndrome is primarily ...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgm228
更新日期:2008-04-01 00:00:00
abstract::Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm303
更新日期:2008-03-01 00:00:00
abstract::Prostate cancer (CaP) is the second leading cause of cancer death in American men. Chronic inflammation has been one of several factors associated with the development of CaP. Single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with increased inflammation, increased cytokine production and po...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm277
更新日期:2008-03-01 00:00:00
abstract::TP63, a member of the TP53 gene family, encodes two groups of three isoforms (alpha, beta and gamma). The TAp63 isoforms act as transcription factors. The DeltaNp63 isoforms lack the main transcription activation domain and act as dominant-negative inhibitors of transactivation (TA) isoforms. To clarify the role of th...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm258
更新日期:2008-02-01 00:00:00
abstract::Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are invol...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm290
更新日期:2008-02-01 00:00:00
abstract::We demonstrated previously that growth factor receptor-bound protein 2 (Grb2) associates with the transforming growth factor-beta (TGF-beta) type II receptor [TbetaR-II] upon its phosphorylation on Tyr284 by Src. Although this phosphotransferase reaction is critical in mediating TGF-beta stimulation of epithelial-mese...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm245
更新日期:2008-02-01 00:00:00
abstract::Little is known about the longitudinal course of hepatitis B virus (HBV) load and its relationship with the development of hepatocellular carcinoma (HCC). We conducted a case-cohort study nested within a cohort of 2874 HBV surface antigen-positive male Taiwanese government employees aged 30 years or older. HBV genotyp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm252
更新日期:2008-01-01 00:00:00
abstract::The possibility that long-term exposure to relatively weak power frequency magnetic fields (MFs) emanating from the generation, transmission and use of electricity could increase the risk of breast cancer is a matter of ongoing debate. Laboratory studies using well-defined exposure conditions are useful to examine whe...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm217
更新日期:2008-01-01 00:00:00
abstract::Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER gene...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm247
更新日期:2008-01-01 00:00:00
abstract::Marked inter-individual variation in lung cancer risk cannot be accounted for solely by cigarette smoke and other environmental exposures. Evidence suggests that variation in bronchial epithelial cell expression of key DNA repair genes plays a role. Variation in these genes correlates with variation in expression of C...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm214
更新日期:2007-12-01 00:00:00